Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling.

Mennatallah O ZakiS El-DesoukyDoaa A ElsherbinyMohamed SalamaSamar S Azab

Published in: Inflammopharmacology (2022)

The current data suggests that GPD exerts a protective effect against tauopathy, behavioural consequences, neurodegeneration, neuroinflammation and apoptosis. GPD is therefore a promising agent for the treatment of neurodegenerative diseases associated with tauopathy.

Keyphrases

signaling pathway
traumatic brain injury
lipopolysaccharide induced
lps induced
cognitive impairment
endoplasmic reticulum stress
cell proliferation
cerebral ischemia
cell cycle arrest
pi k akt
cell death
big data
electronic health record
radiation induced
brain injury
machine learning
artificial intelligence