Safety of antifibrinolytics in cranial vault reconstructive surgery: a report from the pediatric craniofacial collaborative group.
Susan M GoobieFranklyn P CladisChris D GloverHenry HuangSrijaya K ReddyAllison M FernandezDavid ZurakowskiPaul A StrickerHeike Griesnull nullPublished in: Paediatric anaesthesia (2017)
This is the first report of an incidence of postoperative seizures of 0.6% in pediatric cranial vault reconstructive surgery. There was no significant difference in postoperative seizures or seizure-like events in those patients who received the tranexamic acid or aminocaproic acid vs those that did not. This report provides evidence of the safety profile of antifibrinolytic in children having noncardiac major surgery. Caution should prevail however in using antifibrinolytic in high-risk patients. Antifibrinolytic dosage regimes should be based on pharmacokinetic data avoiding high doses.
Keyphrases
- minimally invasive
- coronary artery bypass
- end stage renal disease
- patients undergoing
- surgical site infection
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- young adults
- risk factors
- prognostic factors
- coronary artery disease
- electronic health record
- machine learning
- deep learning
- artificial intelligence
- data analysis