Chiroptical spectroscopic studies for the absolute configuration determination of hexahydrocurcumin and octahydrocurcumin.
Andrew R PuenteNagabhushanam KalyanamSavita GanjihalMuhammed MajeedPrasad L PolavarapuPublished in: Chirality (2022)
Hexahydrocurcumin (HHC) and octahydrocurcumin (OHC) were synthesized, and their enantiomers were separated using supercritical fluid chromatography. The absolute configurations (ACs) of HHC and OHC were independently determined using experimental measurements and quantum theoretical predictions of vibrational circular dichroism, electronic circular dichroism, and optical rotatory dispersion. These studies lead to AC assignments of (-)-(R)-HHC and (+)-(R,R)-OHC. The AC of OHC is further confirmed by its structure determined from single crystal x-ray diffraction.
Keyphrases
- high speed
- high resolution
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- molecular dynamics
- energy transfer
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- liquid chromatography
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- molecularly imprinted
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- capillary electrophoresis
- dual energy
- monte carlo
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