The effect of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea and uncontrolled hypertension - Study design and challenges during the COVID-19 pandemic.
Fernanda C S G CruzLuciano Ferreira DragerDaniel B C QueirózGabriela A SouzaRodrigo Pinto PedrosaTarcya L G Couto PatriotaEgidio L DóreaMarcelo Luiz Campos VieiraCamila Gosenheimer RighiDenis MartinezGeruza A da SilvaGiovanio Vieira da SilvaAndrea Pio de AbreuPaulo Andrade LotufoIsabela Judith Martins BenseñorLuiz Aparecido BortolottoFlávio Danni FuchsGeraldo Lorenzi-FilhoPublished in: Clinics (Sao Paulo, Brazil) (2021)
The MORPHEOS trial has a unique study design including a run-in period; pill counting, and detailed analysis of hypertension-mediated organ damage in patients with uncontrolled HTN that will allow clarification of the impact of OSA treatment with CPAP.