Five-FU@CuS/NH 2 -UiO-66 as a drug delivery system for 5-fluorouracil to colorectal cancer cells.
Marjan GholamiMajid DarroudiAzadeh HekmatMajid KhazeiPublished in: Journal of biochemical and molecular toxicology (2022)
In this study, copper sulfide nanoparticles (CuS-NPs), which can improve the antiproliferative properties of conventional anticancer drugs such as 5-fluorouracil (5-FU), were incorporated into the pores of amine-functionalized UiO-66 (CuS/NH 2 -UiO-66). The introduced nano-drug delivery system was exerted to perform an in vitro treatment on CT-26 mouse colorectal cancer cells. The synthesized final product was labeled as 5-FU@CuS/NH 2 -UiO-66 and characterized through conventional methods including X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET) analysis, Ultraviolet-Visible (UV-Vis) analysis, Inductively coupled plasma mass spectrometry (ICP-MS), and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In contrast to 5-FU, the outcomes of the cytotoxicity assay lacked any comparable results for 5-FU@CuS/NH 2 -UiO-66.
Keyphrases
- metal organic framework
- mass spectrometry
- room temperature
- high resolution
- high throughput
- high performance liquid chromatography
- multiple sclerosis
- magnetic resonance
- dual energy
- liquid chromatography
- computed tomography
- magnetic resonance imaging
- type diabetes
- perovskite solar cells
- contrast enhanced
- adipose tissue
- quantum dots
- molecularly imprinted
- pet imaging
- single cell
- data analysis
- aqueous solution