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SY-1530, a highly selective BTK inhibitor, effectively treats B-cell malignancies by blocking B-cell activation.

Liao WangYinghui SunXijie LiuHongjuan LiChang LuRonghui YangChuanzhen YangBinghui Li
Published in: Cancer biology & medicine (2021)
SY-1530 is an irreversible and selective BTK inhibitor that shows inhibitory effects on B-cell malignancies by blocking the BCR signaling pathway. Therefore, it may be a promising therapeutic approach for the treatment of B-cell malignancies.
Keyphrases
  • tyrosine kinase
  • signaling pathway
  • acute lymphoblastic leukemia
  • pi k akt
  • epithelial mesenchymal transition
  • combination therapy
  • cell proliferation
  • endoplasmic reticulum stress