Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment.
Takao YasuiJumpei MorikawaNoritada KajiManabu TokeshiKazuo TsubotaYoshinobu BabaPublished in: Micromachines (2016)
Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.
Keyphrases
- bone marrow
- cell therapy
- molecularly imprinted
- platelet rich plasma
- end stage renal disease
- single cell
- high throughput
- endothelial cells
- ejection fraction
- newly diagnosed
- induced apoptosis
- chronic kidney disease
- prognostic factors
- risk assessment
- peritoneal dialysis
- cell cycle arrest
- cell proliferation
- mesenchymal stem cells
- combination therapy
- patient reported
- solid phase extraction
- human health
- tandem mass spectrometry