Applications of molecular barcode sequencing for the detection of low-frequency variants in circulating tumour DNA from hepatocellular carcinoma.

Hye-Won LeeEsl KimKyung Joo ChoHye Jung ParkJieun SeoHyeonah LeeEunha BaekJong Rak ChoiKwang-Hyub HanSeung-Tae LeeJun Yong Park

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

ctDNA detection using molecular barcoding technology offers dynamic and personalized information concerning tumour biology, such information can guide clinical diagnosis and management. This detection also has the potential as a minimally invasive approach for prognostic stratification and post-therapeutic monitoring.

Keyphrases

minimally invasive
loop mediated isothermal amplification
real time pcr
label free
single molecule
circulating tumor
healthcare
gene expression
single cell
risk assessment
dna methylation
sensitive detection
social media
robot assisted
human health
circulating tumor cells
quantum dots
nucleic acid