Microstructural Tissue Changes in Alzheimer Disease Brains: Insights from Magnetization Transfer Imaging.

I Colonna Marisa Koini Lukas Pirpamer Anna Damulina Edith Hofer Petra Schwingenshuh Christian Enzinger R Schmidt Stefan Ropele

Published in: AJNR. American journal of neuroradiology (2021)

Alzheimer disease is associated with magnetization transfer ratio reductions in GM and WM regions of the brain. Lower magnetization transfer ratios in the entire cortex and AD-signature regions contribute to cognitive impairment independent of brain atrophy and WM damage.

Keyphrases

white matter
cognitive impairment
resting state
functional connectivity
mild cognitive impairment
high resolution
cerebral ischemia
oxidative stress
multiple sclerosis
electron transfer
mass spectrometry
photodynamic therapy
brain injury