Lycopene Improves Bone Quality and Regulates AGE/RAGE/NF-кB Signaling Pathway in High-Fat Diet-Induced Obese Mice.
Bingke XiaRuyuan ZhuHao ZhangBeibei ChenYage LiuXuan DaiZimengwei YeDan-Dan ZhaoFangfang MoSihua GaoXiang-Dong WangDieter BrommeLili WangXinxiang WangDongwei ZhangPublished in: Oxidative medicine and cellular longevity (2022)
Lycopene may improve bone quality through its antioxidant properties, which may be linked with the regulation of the AGE/RAGE/NF-кB signaling pathway in obese mice. These results suggest that lycopene consumption may be beneficial for the management of obesity-induced osteoporosis.
Keyphrases
- signaling pathway
- high fat diet induced
- pi k akt
- bone mineral density
- insulin resistance
- induced apoptosis
- postmenopausal women
- epithelial mesenchymal transition
- oxidative stress
- metabolic syndrome
- quality improvement
- soft tissue
- diabetic rats
- type diabetes
- bone loss
- high glucose
- cell proliferation
- lps induced
- adipose tissue
- bone regeneration
- skeletal muscle
- nuclear factor
- inflammatory response