Review article: bugs, inflammation and mood-a microbiota-based approach to psychiatric symptoms in inflammatory bowel diseases.
Anne Kerstin ThomannWing Yan Joyce MakJing Wan ZhangTorsten WuestenbergMatthias P EbertJoseph J Y SungÇharles N BernsteinWolfgang ReindlWilliam K K WuPublished in: Alimentary pharmacology & therapeutics (2020)
Both IBD and mental disorders are associated with gut microbial alterations. Preclinical and preliminary human studies have shown a mediating role of the gut microbiota in intestinal inflammation and anxiety, depression and stress. Targeting the gut microbiota may represent a useful therapeutic approach for the treatment of psychiatric co-morbidities in IBD.
Keyphrases
- sleep quality
- oxidative stress
- mental health
- endothelial cells
- depressive symptoms
- microbial community
- bipolar disorder
- induced pluripotent stem cells
- ulcerative colitis
- cancer therapy
- cell therapy
- physical activity
- stem cells
- stress induced
- mesenchymal stem cells
- combination therapy
- heat stress
- bone marrow
- replacement therapy
- smoking cessation