Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS).
Lenka A VodstrcilThusitha W T RupasingheFabian Y S KongDedreia TullKaren WorthingtonMarcus Y ChenWilhelmina M HustonPeter TimmsMalcolm J McConvilleChristopher K FairleyCatriona S BradshawSepehr N TabriziJane S HockingPublished in: PloS one (2017)
Our study confirmed that a single 1g dose of azithromycin is rapidly absorbed and remains in the vagina at relatively high levels for at least a week, suggesting that poor antibiotic absorption is unlikely to be an explanation for treatment failure.