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Stimulus-responsive nano lipidosome for enhancing the anti-tumour effect of a novel peptide Dermaseptin-PP.

Changhai WangZiyi DongQing ZhangMingxue GuoWenjun HuShuang DongTangthianchaichana JakkreeYang LuShouying Du
Published in: IET nanobiotechnology (2023)
Der-loaded-pHSL designed in this study is a liposome with a quick, simple, effective preparation method, which can significantly reduce the haemolytic toxicity of Dermaseptin-PP and enhance its antitumour effect by increasing the tumour accumulation and cell intake. It provides a new idea for applying Dermaseptin-PP and other anticancer peptides with α-helical structure.
Keyphrases
  • cancer therapy
  • drug delivery
  • single cell
  • oxidative stress
  • stem cells
  • molecularly imprinted
  • body mass index
  • amino acid