Laburnicotides A-F: Acyclic N -Acetyl Oligopeptides from the Nematode-Cyst-Associated Fungus Laburnicola nematophila .
Caren HolzenkampJan-Peer WennrichJackson M MuemaSamad AshrafiWolfgang MaierMarc StadlerSherif Saeed EbadaPublished in: ACS omega (2024)
Nematode-associated fungi revealed the potential to produce a broad spectrum of chemical scaffolds. In this study, a mycelial extract of Laburnicola nematophila , a fungal strain derived from the cereal cyst nematode Heterodera filipjevi , was chemically explored and afforded six unprecedentedly reported acylic N -acetyl oligopeptides, laburnicotides A-F ( 1 - 6 ). Structure elucidation of the isolated compounds was established based on comprehensive 1D and 2D NMR spectroscopic analyses together with the acquired HR-ESI-MS spectrometric data. The absolute configuration of amino acid residues in 1 - 6 was established by performing advanced Marfey's derivatization method. All isolated compounds were assessed for their cytotoxic, antimicrobial, antiviral, and nematicidal activities with no potential activity observed.
Keyphrases
- ms ms
- amino acid
- mass spectrometry
- liquid chromatography
- high performance liquid chromatography
- magnetic resonance
- gas chromatography
- multiple sclerosis
- staphylococcus aureus
- molecular docking
- oxidative stress
- single cell
- high resolution
- human health
- liquid chromatography tandem mass spectrometry
- simultaneous determination
- risk assessment
- tissue engineering
- deep learning
- artificial intelligence
- data analysis
- high resolution mass spectrometry