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Genetic variation in the immune system and malaria susceptibility in infants: a nested case-control study in Nanoro, Burkina Faso.

Hamatandi Magloire NatamaEduard Rovira-VallbonaMeryam KritPieter GuetensHermann SorghoM Athanase SoméMaminata Traoré-CoulibalyInnocent ValéaPetra F MensHenk D F H SchalligDirk BerkvensLuc KestensHalidou TintoAnna Rosanas-Urgell
Published in: Malaria journal (2021)
These findings indicate that genetic polymorphisms in genes driving innate immune responses are associated to malaria susceptibility during the first year of life, possibly by modulating production of inflammatory mediators.
Keyphrases
  • immune response
  • plasmodium falciparum
  • dendritic cells
  • genome wide
  • oxidative stress
  • dna methylation
  • gene expression
  • inflammatory response
  • genome wide analysis