Pin1 promotes pancreatic cancer progression and metastasis by activation of NF-κB-IL-18 feedback loop.
Qiqing SunGuixiong FanQifeng ZhuoWeixing DaiZeng YeShunrong JiWenyan XuWensheng LiuQiangsheng HuZheng ZhangMengqi LiuXian-Jun YuXiao-Wu XuYi QinPublished in: Cell proliferation (2020)
Our study improves the understanding of Pin1 in tumour-promoting inflammation in PDAC, which is a hallmark of cancer; Pin1 interacted with p65 in PDAC and enhanced NF-κB signalling and downstream transcriptional activation of IL-18, with increased IL-18 continuously activating NF-κB signalling, which then forms a positive feedback loop.