Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes.

Caroline KratkaDavid DrutovicCecilia S BlenginiKaren Schindler

Published in: BMC research notes (2022)

ZC treatment caused defects in meiotic progression and spindle building. By Western blotting and immunofluorescence, we observed that activated AURKA and AURKC levels in ZC-treated oocytes decreased compared to controls. These results suggest there is a population of AURKA-CPC in mouse oocytes. These data together suggest that INCENP-dependent AURKA and AURKC activities are needed for spindle bipolarity and meiotic progression.

Keyphrases

south africa
electronic health record
copy number
tyrosine kinase
gene expression
machine learning
oxide nanoparticles
newly diagnosed