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Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study.

Nanfang PanKun QinLuis R PatinoMaxwell J TallmanDu LeiLu LuWenbin LiThomas J BlomKaitlyn M BrunsJeffrey A WelgeJeffrey R StrawnQi-Yong GongJohn A SweeneyManpreet Kaur SinghMelissa P DelBello
Published in: Journal of child psychology and psychiatry, and allied disciplines (2024)
Our findings of abnormal connectome organization in the DMN and VN may advance mechanistic understanding of risk for BD. Neuroimaging biomarkers of increased network segregation in the SFG and altered topological centrality in the insula and hippocampus in broader limbic systems may be used to target interventions tailored to mitigate the underlying risk of brain abnormalities in these at-risk youth.
Keyphrases
  • resting state
  • functional connectivity
  • bipolar disorder
  • physical activity
  • young adults
  • white matter
  • major depressive disorder
  • early onset
  • cognitive impairment
  • blood brain barrier