The effect of sodium-glucose cotransporter 2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes mellitus on cardiovascular and renal outcomes: A systematic review and meta-analysis.

Javier Ignacio Castillo Horna Marcelo Reategui-Diaz Franco Ronald Romaní RomaníLarry Prokop

Published in: PloS one (2023)

In patients with CKD, treatment with SGLT-2 inhibitors in addition to standard therapy conferred protection against cardiovascular and renal outcomes. Further research on patients with non-diabetic CKD should be done to confirm the utility of these medications in this population. (PROSPERO ID: CRD42021275012).

Keyphrases

chronic kidney disease
type diabetes
glycemic control
stem cells
metabolic syndrome
wound healing
replacement therapy