Human Milk Oligosaccharide Disialyllacto-n-tetraose Protects Human Intestinal Epithelium Integrity and Permeability against Mast Cell Chymase-induced Disruption by Stabilizing ZO-1/FAK/P38 Pathway of Intestinal Epithelial Cell.

Xuejiao LianWenting ZhangJingqiu He-YangXiaoying Zhou

Published in: Immunopharmacology and immunotoxicology (2022)

Chymase-positive MCs are involved in IBD progress. MC-chymase disrupts intracellular ZO-1/FAK/P38 signal pathway and cell-cell/cell-matrix contacts, while DSLNT protects intestinal-epithelium against MC-chymase to maintain the intestinal epithelium integrity.

Keyphrases

single cell
human milk
endothelial cells
cell therapy
stem cells
high glucose
oxidative stress
drug induced
ulcerative colitis
preterm birth