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Association of circulating Z-polymer with adverse clinical outcomes and liver fibrosis in adults with alpha-1 antitrypsin deficiency.

Malin FrommeLaura RademacherSamira AmzouChristi D CookIsabel ZachariasLanju ZhangJohn E RipollonePavel Strnad
Published in: United European gastroenterology journal (2024)
In adults with the PiZZ genotype, higher circulating Z-polymer levels were associated with a shorter time to adverse clinical outcome, and positively correlated with baseline LSM. Circulating Z-polymer levels may be a prognostic biomarker of clinically relevant disease in AATD.
Keyphrases
  • liver fibrosis
  • drug induced