Assessment of cytotoxicity and sensitization potential of intradermally injected tattoo inks in reconstructed human skin.

Joey J J P KarregatThomas RustemeyerSebastiaan A S van der BentSander W SpiekstraMaria ThonDavid Fernandez Rivas Susan Gibbs

Published in: Contact dermatitis (2021)

Using the RHS model system, four tattoo inks were identified as highly cytotoxic and classified as potential sensitizers, suggesting that allergic contact dermatitis could emerge in individuals carrying these inks. These results indicate that an RHS-based assessment of cytotoxicity and sensitization potential by intradermal tattoo ink injection is a useful analytical tool to determine ink-induced deleterious effects.

Keyphrases

human health
risk assessment
oxidative stress
climate change
endothelial cells