USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4.

Tingzheng PanXuetao LiYanyan LiZhennan TaoHui YaoYue WuGuangliang ChenKai ZhangYouxin ZhouYulun Huang

Published in: Cancer cell international (2021)

Targeted inhibition of USP7 enhances the ubiquitination of ARF4 and ultimately mediates the apoptosis of GBM cells. In a clinical sense, P5091 as a novel specific inhibitor of USP7 may be an effective approach for the treatment of GBM.

Keyphrases

cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
cell death
oxidative stress
pi k akt
signaling pathway
cell proliferation