Pathogenic effect of TP73 Gene Variants in People With Amyotrophic Lateral Sclerosis.
Kristi L RussellJonathan M DownieSummer B GibsonSpyridoula TsetsouMatthew D KeefeJerry A DuranKarla P FigueroaMark B BrombergL Charles MurtaughJoshua Leith BonkowskyStefan M PulstLynn B JordePublished in: Neurology (2021)
Together, these results strongly suggest that variants in TP73 correlate with risk for ALS and indicate a novel role for apoptosis in ALS disease pathology.