Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids.

Atthapol SrimongkolNatanan LaosillapacharoenDuangporn SaengwimolVijender ChaitankarDuangnate RojanapornThanastha ThanomchardSuparerk BorwornpinyoSuradej HongengRossukon Kaewkhaw

Published in: Journal of experimental & clinical cancer research : CR (2023)

The efficacy and retinal toxicity profiles of sunitinib suggest that it could potentially be repurposed for local chemotherapy of RB.

Keyphrases

renal cell carcinoma
metastatic renal cell carcinoma
oxidative stress
optical coherence tomography
radiation therapy
oxide nanoparticles
induced pluripotent stem cells