Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.
Jihoon NahAkihiro ShirakabeRisa MukaiPeiyong ZhaiEun Ah SungAndreas IvessaWataru MizushimaYasuki NakadaToshiro SaitoChengchen HuYong Keun JungJunichi SadoshimaPublished in: Cardiovascular research (2022)
Ulk1-mediated alternative mitophagy is a major mechanism mediating mitophagy in response to PO and plays an important role in mediating mitochondrial quality control mechanisms and protecting the heart against cardiac dysfunction.