Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice.

Michael K SchuhmannMichael BieberMaximilian FrankeAlexander M KollikowskiDavid StegnerKatrin G HeinzeBernhard NieswandtMirko PhamGuido Stoll

Published in: Journal of neuroinflammation (2021)

Progressive brain infarction can be delayed by blocking detrimental lymphocyte/platelet responses already during occlusion paving the way for ultra-early treatment strategies in hyper-acute stroke before recanalization.

Keyphrases

middle cerebral artery
multiple sclerosis
internal carotid artery
peripheral blood
white matter
high fat diet induced
resting state
high resolution
type diabetes
mass spectrometry
cerebral ischemia
metabolic syndrome
wild type