Genetic Determinants of Antibody-Mediated Immune Responses to Infectious Diseases Agents: A Genome-Wide and HLA Association Study.

Guillaume Butler-LaporteDevin KreuzerTomoko NakanishiAdil HarroudVincenzo ForgettaJ Brent Richards

Published in: Open forum infectious diseases (2020)

We have identified multiple genetic variants associated with antibody immune response to 13 infections, many of which are biologically plausible therapeutic or vaccine targets. This may help prioritize future research and drug development.

Keyphrases

immune response
genome wide
infectious diseases
dna methylation
dendritic cells
toll like receptor
copy number
current status