The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression.

Irene Peñuelas-HaroRut Espinosa-SoteloEva Crosas-MolistMacarena Herranz-ItúrbideDaniel Caballero-DíazAnia AlayXavier SoléEmilio RamosTeresa SerranoMaría Luz Martínez-ChantarUlla G KnausJosé M CuezvaAntonio ZorzanoEsther BertranIsabel Fabregat

Published in: Hepatology (Baltimore, Md.) (2022)

Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC-dependent manner to promote HCC progression.

Keyphrases

reactive oxygen species
oxidative stress
transcription factor