Network pharmacology and molecular docking study for biological pathway detection of cytotoxicity of the yellow jasmine flowers.
Seham S El-HawaryMarzough A AlbalawiAyat O S MontasserShaimaa R AhmedSumera QasimAli A ShatiMohammad Y AlfaifiSerag Eldin I ElbehairiOmnia F HassanAbdelfattah A SadakahFatma Alzahraa MokhtarPublished in: BMC complementary medicine and therapies (2023)
Our findings suggest that J. humile suppresses breast cancer proliferation and induces cell cycle arrest and apoptosis partly by EGFR signaling pathway, highlighting J. humile as a potential therapeutic candidate against breast cancer.
Keyphrases
- cell cycle arrest
- signaling pathway
- pi k akt
- molecular docking
- cell death
- small cell lung cancer
- molecular dynamics simulations
- induced apoptosis
- epithelial mesenchymal transition
- cell proliferation
- epidermal growth factor receptor
- tyrosine kinase
- oxidative stress
- endoplasmic reticulum stress
- real time pcr
- breast cancer risk
- loop mediated isothermal amplification
- sensitive detection
- quantum dots
- network analysis