Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress.

Kelsey HazeghFang FangMarjorie D BravoJohnson Q Tran Marcus O Muench Rachael P Jackman Nareg H RoubinianLorenzo BertoloneAngelo D'AlessandroLarry DumontGrier P PageTamir Kanias

Published in: Transfusion (2020)

Obesity is associated with significant changes in RBC metabolism and increased susceptibility to hemolysis under routine storage of RBC units. The impact on transfusion efficacy warrants further evaluation.

Keyphrases

red blood cell
insulin resistance
metabolic syndrome
oxidative stress
weight loss
high fat diet induced
type diabetes
weight gain
cardiac surgery
dna damage
adipose tissue
ischemia reperfusion injury
body mass index
sickle cell disease
induced apoptosis
heat shock protein