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Knockdown of KLF5 promotes cisplatin-induced cell apoptosis via regulating DNA damage checkpoint proteins in non-small cell lung cancer.

Hao ZhangFei ShaoWei GuoYibo GaoJie He
Published in: Thoracic cancer (2019)
KLF5 plays a significant role in the DNA damage response by regulating DNA damage checkpoint proteins. Inhibition of KLF5 may be a potential therapeutic target for NSCLC patients with cisplatin resistance.
Keyphrases
  • dna damage
  • dna damage response
  • dna repair
  • transcription factor
  • oxidative stress
  • small cell lung cancer
  • advanced non small cell lung cancer
  • cell cycle
  • risk assessment
  • brain metastases