Dietary Caffeine and Brain Dopaminergic Function in Parkinson Disease.
Emmi K SaarinenTomi KuusimäkiKari LindholmKalle J NiemiEmma A HonkanenTommi NoponenMarko SeppänenToni IhalainenKirsi MurtomäkiTuomas H MertsalmiElina JaakkolaElina MyllerMikael EklundSimo NuuttilaReeta LevoKallol Ray ChaudhuriAngelo AntoniniTero VahlbergMarko LehtonenJuho JoutsaFilip ScheperjansValtteri KaasinenPublished in: Annals of neurology (2024)
Chronic caffeine intake prompts compensatory and cumulative dopamine transporter downregulation, consistent with caffeine's reported risk reduction in Parkinson disease. However, this decline does not manifest in symptom changes. Transiently increased dopamine transporter binding after recent caffeine intake has implications for dopaminergic imaging guidelines. ANN NEUROL 2024;96:262-275.