Familial trigeminal neuralgia - a systematic clinical study with a genomic screen of the neuronal electrogenisome.

Giulia Di StefanoJun-Hui YuanGiorgio CruccuStephen G WaxmanSulayman D Dib-HajjAndrea Truini

Published in: Cephalalgia : an international journal of headache (2020)

Our results suggest that familial occurrence of trigeminal neuralgia is more common than previously considered. Although our results demonstrate variants in genes encoding voltage-gated ion channels and transient receptor potential channels within these patients, further study will be needed to determine their roles in the pathogenesis of trigeminal neuralgia.

Keyphrases

neuropathic pain
end stage renal disease
ejection fraction
newly diagnosed
early onset
copy number
chronic kidney disease
risk assessment
prognostic factors
cerebral ischemia
peritoneal dialysis
clinical trial
dna methylation
gene expression
human health
patient reported