Osteopontin: Relation between Adipose Tissue and Bone Homeostasis.
Carolina De FuscoAntonietta MessinaVincenzo MondaEmanuela ViggianoFiorenzo MoscatelliAnna ValenzanoTeresa EspositoChieffi SergioGiuseppe CibelliMarcellino MondaGiovanni MessinaPublished in: Stem cells international (2017)
Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.
Keyphrases
- bone mineral density
- adipose tissue
- insulin resistance
- postmenopausal women
- weight loss
- metabolic syndrome
- body composition
- high fat diet
- type diabetes
- soft tissue
- bone loss
- healthcare
- bone regeneration
- drug delivery
- mental health
- public health
- induced apoptosis
- bariatric surgery
- protein protein
- skeletal muscle
- binding protein
- cell death
- cell cycle arrest
- small molecule
- physical activity
- social media
- health information
- signaling pathway
- cell proliferation
- cancer therapy