Hesperidin Supplementation Improves Altered PON -1, LDL Oxidation, Inflammatory Response and Hepatic Function in an Experimental Rat Model of Hyperlipidemia.
Raushan KumarMohammad Idreesh KhanFauzia AshfaqAbdulrahman A AlsayeghFahmida KhatoonTahani Nasser AltamimiSyed Ibrahim RizviPublished in: Indian journal of clinical biochemistry : IJCB (2023)
In this study, we have examined the effect of hesperidin on rats fed on an experimental high-fat diet. Male Wistar rats were given a high-fat diet orally for one month for developing an HFD (High fat- diet) model. Rats were also supplemented with hesperidin (100 mg/kg body weight) for one month. We determined serum LDL (Low-density lipoprotein) oxidation, Paraoxonase-1 (PON-1) activity, and histopathological profile of the liver. Inflammatory cytokines levels were also measured in serum. HFD induced significant changes in LDL oxidation and PON-1 activity. Liver tissue histopathology and gene expression of inflammatory markers (Il-6(Interleukin-6), TNF- alpha (Tumor necrosis factor alpha), NF-KB (Nuclear factor kappa B) show that significant changes occur in the hyperlipidemic model of rats. We also show that hesperidin can effectively improve plasma antioxidant, LDL oxidation, and inflammatory cytokine expression in rats already subjected to hyperlipidemic stress. We conclude that hesperidin may protect the liver from oxidative stress by improving hepatic function.
Keyphrases
- high fat diet
- nuclear factor
- low density lipoprotein
- oxidative stress
- adipose tissue
- insulin resistance
- gene expression
- inflammatory response
- toll like receptor
- body weight
- hydrogen peroxide
- rheumatoid arthritis
- diabetic rats
- signaling pathway
- dna damage
- skeletal muscle
- type diabetes
- binding protein
- high glucose
- ischemia reperfusion injury
- long non coding rna
- drug induced
- electron transfer
- stress induced
- cell proliferation