Hydrogel-Embedded Poly(Lactic- co -Glycolic Acid) Microspheres for the Delivery of hMSC-Derived Exosomes to Promote Bioactive Annulus Fibrosus Repair.

Tyler J DiStefanoKeti VasoChristopher J PanebiancoGeorge DaniasHenry N ChionumaKuriakose KunnathStylianos Z KarouliasMinghui WangPeng XuRajesh N DavéSusmita SahooJennifer R WeiserJames C Iatridis

Published in: Cartilage (2022)

This MSC-Exo treatment strategy may offer benefits of stem cell therapy without the need for exogenous stem cell transplantation by stimulating cell proliferation, promoting cell migration, and protecting cells from the degenerative proinflammatory microenvironment.

Keyphrases

stem cell transplantation
cell therapy
cell migration
stem cells
cell proliferation
mesenchymal stem cells
high dose
drug delivery
high resolution
combination therapy
wound healing
hyaluronic acid