Transplantation of Human Urine-Derived Stem Cells Ameliorates Erectile Function and Cavernosal Endothelial Function by Promoting Autophagy of Corpus Cavernosal Endothelial Cells in Diabetic Erectile Dysfunction Rats.
Chi ZhangDaosheng LuoTingting LiQiyun YangYun XieHaicheng ChenLinyan LvJiahui YaoCuncan DengXiaoyan LiangRongpei WuXiangzhou SunYuanyuan ZhangChunhua DengGuihua LiuPublished in: Stem cells international (2019)
Impaired autophagy is involved in the cavernosal endothelial dysfunction and erectile dysfunction of DED rats. Intracavernous injection of USCs upregulates autophagic activity in the cavernosal endothelium, contributing to ameliorating cavernosal endothelial dysfunction and finally improving the erectile dysfunction induced by diabetes.
Keyphrases
- endothelial cells
- cell death
- stem cells
- type diabetes
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- cardiovascular disease
- nitric oxide
- mouse model
- adipose tissue
- glycemic control
- induced pluripotent stem cells
- metabolic syndrome
- ultrasound guided
- skeletal muscle
- vascular endothelial growth factor
- mesenchymal stem cells