Somatic mutational profiles and germline polygenic risk scores in human cancer.

Yuxi LiuAlexander GusevYujing J HengLudmil B AlexandrovPeter Kraft

Published in: Genome medicine (2022)

Our analysis suggests that there are robust associations between tumor somatic mutational profiles and germline PRS. These may reflect the mechanisms through hormone regulation and immune responses that contribute to cancer etiology and drive cancer progression.

Keyphrases

papillary thyroid
immune response
squamous cell
endothelial cells
lymph node metastasis
gene expression
childhood cancer
young adults
oxidative stress
inflammatory response
data analysis