Altered spike IgG Fc N-linked glycans are associated with hyperinflammatory state in adult COVID and Multisystem Inflammatory Syndrome in Children.

Jacob D ShermanVinit KarmaliBhoj KumarTrevor W SimonSarah BechnakAnusha PanjwaniCaroline R CiricDongli WangChris HuertaBrandi JohnsonEvan J AndersonNadine G RouphaelMatthew H CollinsChristina A Rostad Parastoo Azadi Erin M Scherer

Published in: medRxiv : the preprint server for health sciences (2024)

We identified previously undescribed relationships between spike IgG glycan modifications and inflammatory cytokines/chemokines that expand our understanding of IgG glycosylation changes that may impact COVID and MIS-C immunopathology.

Keyphrases

coronavirus disease
sars cov
cell surface
oxidative stress
respiratory syndrome coronavirus
case report