Synthesis and characterization of a novel antibacterial material containing poly(sulfobetaine) using reverse atom transfer radical polymerization.
Xiaohong ChuMing ZhangChangzhu WuFan WuBaohong SunJian ShenPublished in: RSC advances (2018)
A novel antibacterial agent was synthesized using 2-(dimethylamino)ethyl methacrylate (DM) and sodium 3-chloro-2-hydroxypropane sulfonate (CHPS). It was characterized by Fourier transform infrared spectroscopy (FTIR), NMR Spectroscopy ( 1 H NMR), and X-ray photoelectron spectroscopy (XPS). This new agent DMCHPS was then grafted onto a polyurethane (PU) substrate via surface-initiated reverse atom transfer radical polymerization (SI-RATRP). The modified PU was characterized by FTIR and XPS. The hydrophilic properties of the PU surface before and after the incorporation of DMCHPS were determined by static contact angle (SCA) measurements. The results showed that the hydrophilicity of the PU surface after the modification was remarkably improved. MIC tests and bacterial adhesion confirmed that modified PU has good antibacterial properties. Protein adsorption experiments show that the material has a certain ability to resist pollution. Furthermore, the high survival rate of HEK293 human embryonic kidney cells shows that the modified PU has a potential use as a medicinal material.
Keyphrases
- high resolution
- silver nanoparticles
- heavy metals
- induced apoptosis
- endothelial cells
- molecular dynamics
- risk assessment
- anti inflammatory
- type diabetes
- solid state
- escherichia coli
- computed tomography
- signaling pathway
- mass spectrometry
- single molecule
- small molecule
- pseudomonas aeruginosa
- biofilm formation
- binding protein
- cell cycle arrest
- room temperature
- insulin resistance
- structural basis
- dual energy
- electron microscopy
- tandem mass spectrometry