The Utility of Preoperative Tumor Markers in Peritoneal Carcinomatosis from Primary Appendiceal Adenocarcinoma: an Analysis from the US HIPEC Collaborative.
Nadege FackcheRyan K SchmockerBoateng KubiJordan M CloydAhmed AhmedTravis GrotzJennifer LeitingKeith FournierAndrew J LeeBenjamin PowersSean DineenJula VeerapongJoel M BaumgartnerCallisia ClarkeT Clark GamblinSameer H PatelVikrom DharRyan J HendrixLaura LambertDaniel E AbbottCourtney PokrzywaKelly LafaroByrne LeeMohammad Y ZaidiShishir K MaithelFabian M JohnstonJonathan B GreerPublished in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2021)
Elevated preoperative CA19-9 portends worse PFS, while elevated CEA predicts worse OS after CRS/HIPEC in patients with MACA. This study provides additional evidence that CA19-9 and CEA levels should be collected during standard preoperative bloodwork, while CA-125 can likely be omitted. Tumor differentiation, when added to preoperative tumor marker levels, provides powerful prognostic information. Prospective studies are required to confirm this association.