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Poly (ADP-ribose) polymerase (PARP) as target for the treatment of epithelial ovarian cancer: what to know.

Luigi Della CorteVirginia ForesteClaudia Di FilippoPierluigi GiampaolinoGiuseppe Bifulco
Published in: Expert opinion on investigational drugs (2021)
In recent years, there is increasing evidence that PARP inhibitor therapy can have life-long percussion in the treatment of EOC, even if some questions have to be solved yet, such as its use in combination therapy, the possibility to retreat with a PARP inhibitor, and finally how to overcome a resistance mechanism to this therapy. In this way, PARP inhibitors can obtain an important role in making a personalized therapeutic program in the case of first-line, neoadjuvant, platinum-sensitive, and resistant high-grade serous OC treatment.
Keyphrases
  • combination therapy
  • high grade
  • dna damage
  • dna repair
  • lymph node
  • low grade
  • radiation therapy
  • quality improvement
  • bone marrow
  • locally advanced