Innate Immune and Neuronal Genetic Markers Are Highly Predictive of Postoperative Pain and Morphine Patient-Controlled Analgesia Requirements in Indian but Not Chinese or Malay Hysterectomy Patients.
Daniel T BarrattAlex T SiaEne-Choo TanAndrew Alexander SomogyiPublished in: Pain medicine (Malden, Mass.) (2022)
This is the highest known value reported for genetic contributions (38%) to morphine use in the acute postoperative pain setting. Our findings highlight the need to incorporate both genetic and nongenetic factors and consider ethnicity-dependent and nonadditive genotypic models in the assessment of factors that contribute to variability in opioid use.
Keyphrases
- postoperative pain
- innate immune
- genome wide
- end stage renal disease
- copy number
- newly diagnosed
- liver failure
- case report
- prognostic factors
- dna methylation
- gene expression
- respiratory failure
- pain management
- drug induced
- hepatitis b virus
- intensive care unit
- chronic pain
- brain injury
- mechanical ventilation
- ultrasound guided
- patient reported