Gamma Knife Radiosurgery does not alter the copy number aberration profile in sporadic vestibular schwannoma.

Aril Løge HåvikOve BrulandDhanushan DhayalanMorten Lund-JohansenPer-Morten Knappskog

Published in: Journal of neuro-oncology (2020)

GKRS is not associated with an increase in CNAs or alteration of the CNA profile in VS, lending support to its low risk. This also implies that there is no major issue with GKRS treatment failure being due to CNAs. In agreement with previous studies, chromosome 22 aberration is the only recurrent CNA. VS consist of several genetic clones, addressing the need for further studies on the composition of cells in this tumor.

Keyphrases

copy number
mitochondrial dna
genome wide
induced apoptosis
case control
dna methylation
cell cycle arrest
brain metastases
gene expression
cell death
signaling pathway
oxidative stress
hearing loss
early onset