Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes.

Matthew MollJulian HeckerJohn PlatigJingzhou ZhangAuyon J GhoshKatherine A PratteRui-Sheng WangDavin HillIain R KonigsbergJoe W ChilesCraig P HershPeter J CastaldiKimberly GlassJennifer G DyDon D SinRuth Tal-SingerMajd MoudedStephen I RennardGary P AndersonGregory L KinneyRussell P BowlerJeffrey L CurtisMerry-Lynn McDonaldEdwin K SilvermanBrian D HobbsMichael H Cho

Published in: medRxiv : the preprint server for health sciences (2024)

Concomitant use of polygenic and transcriptional risk scores identified clinical and molecular heterogeneity amongst high-risk individuals. Proteomic and drug repurposing analysis identified subtype-specific enrichment for therapies and suggest prior drug repurposing failures may be explained by patient selection.

Keyphrases

chronic obstructive pulmonary disease
gene expression
transcription factor
case report
single cell
adverse drug
lung function
cystic fibrosis
single molecule
air pollution
electronic health record