Safety of drugs used for the treatment of migraine during pregnancy: a narrative review.

Obtaining high quality drug safety data in pregnant migraineurs is difficult not least because exposing a fetus to research related risks is often considered unethical. There is reliance on observational studies which often group drugs together and lack specificities pertinent to drug prescribing like timing, dosing and duration. Improved statistical tools, study designs and the creation of international collaborative frameworks are ways to advance knowledge on drug safety in pregnancy.