Characterization and genetic analysis of extensively drug-resistant hospital acquired Pseudomonas aeruginosa isolates.

Mai A Abdelaziz Abeer M Abd El-Aziz Mohamed Mohamed Adel El-Sokkary Rasha Fathy Barwa

Published in: BMC microbiology (2024)

The present study revealed a high prevalence of XDR-PA in hospital settings which were resistant to a variety of antibiotics due to several mechanisms. In addition, 98% of the XDR-PA clinical isolates contained at least one gene associated with movable genetic elements, which could have aided the evolution of these XDR-PA strains. To reduce spread of drug resistance, judicious use of antimicrobial agents and strict infection control measures are therefore essential.

Keyphrases

drug resistant
multidrug resistant
acinetobacter baumannii
pseudomonas aeruginosa
genome wide
healthcare
copy number
staphylococcus aureus
cystic fibrosis
escherichia coli
adverse drug
biofilm formation
single cell
emergency department
gene expression
genetic diversity
drug induced