Adipose tissue-derived stem cells protect the primordial follicle pool from both direct follicle death and abnormal activation after ovarian tissue transplantation.

Luciana CacciottolaGuillaume E CourtoyThu Y T NguyenCamille HossayJacques Donnez Marie-Madeleine Dolmans

Published in: Journal of assisted reproduction and genetics (2020)

We demonstrate that ASCs exert positive effects on the ovarian reserve, not only by protecting primordial follicles from direct death but also by maintaining their quiescence through modulation of the PI3K/Akt pathway.

Keyphrases

stem cells
adipose tissue
germ cell
cell therapy
insulin resistance
high fat diet
type diabetes
bone marrow
mesenchymal stem cells