Combating a Master Manipulator: Staphylococcus aureus Immunomodulatory Molecules as Targets for Combinatorial Drug Discovery.
Kadalipura P RakeshManukumar Honnayakanahalli MarichannegowdaShobhith SrivastavaXing ChenSihui LongChimatahalli S KarthikPutswamappa MalluHua-Li QinPublished in: ACS combinatorial science (2018)
Staphylococcus aureus is a bacterial pathogen that can cause significant disease burden and mortality by counteracting host defenses through producing virulence factors to survive the immune responses evoked by infection. This emerging drug-resistant pathogen has led to a decline in the efficacy of traditional antimicrobial therapy. To combat these threats, precision antimicrobial therapeutics have been created to target key virulence determinants of specific pathogens. Here we review the benefits of, progresses in, and roadblocks to the development of precision antimicrobial therapeutics using combinatorial chemistry.
Keyphrases
- staphylococcus aureus
- drug resistant
- drug discovery
- biofilm formation
- multidrug resistant
- immune response
- methicillin resistant staphylococcus aureus
- acinetobacter baumannii
- small molecule
- candida albicans
- gram negative
- risk factors
- antimicrobial resistance
- cardiovascular events
- toll like receptor
- coronary artery disease
- cystic fibrosis
- inflammatory response
- smoking cessation